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Gelsolin (GSN) is an actin binding protein that regulates actin-severing/depolymerizing in a calcium dependent manner, and acts as a multifunctional regulator for cell metabolism and survival. Gelsolin exists in two isoforms: a cytoplasmic gelsolin (cGSN; 80-90 kDa) and a plasma gelsolin (pGSN; 93 kDa), differing at N terminal residues. Decreased levels of pGSN are strongly associated with human diseases, such as, acute liver injury, major trauma, myocardial infarction, inflammation, lung injury, rheumatoid arthritis, hemodialysis, multiple sclerosis, Alzheimer's disease.

Synonyms: Actin depolymerizing factor, ADF, AGEL,GSN

Attribute: Rabbit Polyclonal Antibody

Isotype: IgG

Purity: Antigen Affinity Purification

Application: ELISA, WB, IP

Calculated MW: 80kDa

Observed MW: 80kDa

Reactivity: Human,Mouse,Rat,Zebra fish

Immunogen: Recombinant Human Gelsolin protein expressed by E.Coli   

Buffer: PBS with 0.1% sodium azide and 50% glycerol, pH 7.2

Storage: Store at -20℃. Do not aliquot

Recommended Dilution:

WB: 1:1000-2000

IP: 1:5000-10000

IF: 1:100-200