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Background: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons.

Host species/Isotype: Mouse/IgG

Species reactivity: Human

Immunogen: KLH conjugated synthetic peptide derived from human p53.

 Storage instructions: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Concentration:1mg/ml

Purity: affinity purified by Protein A

Clonality: Monoclonal

Molecular weight: 53KDa

Tested applications:

WB=1:500-1000

ELISA=1:500-1000