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商品編號


AG-20T-0209-C050



品牌


Adipogen



公司


Adipogen



公司分類


Antibodies



Size

50 ?g

商品信息


More Information



Product Details



Synonyms

UBB; Ubiquitin B



Product Type

Monoclonal Antibody



Properties



Clone

1001c



Isotype

Rabbit IgG



Immunogen/Antigen

K48-linkage from human ubiquitin.



Application


Western Blot:
(0.1-0.5?g/ml)




Crossreactivity

All
Human



Specificity

Recognizes endogenous human proteins containing K48-linked polyubiquitin chains, but has no cross-reactivity to monoubiquitin or polyubiquitin of other linkages.



Purity Detail

Protein A purified.



Formulation

Liquid. In PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.



Declaration

Manufactured by Boston Biochem



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Aliquot to avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Polyubiquitin chains are composed of ubiquitin monomers that are covalently linked through isopeptide bonds (other than linear, or “Met1-linked” polyubiquitin). Isopeptides are formed between a lysine residue of one ubiquitin molecule and the C-terminal glycine residue of another ubiquitin molecule. Seven of the seventy-six amino acids in ubiquitin are lysine residues that can participate in polyubiquitin chain formation. Linkage through specific lysine residues is thought to serve as a signal that affects protein degradation, signaling, trafficking, and other cellular processes. K48-linked polyubiquitin chains attached to substrate proteins often serve as a recognition sequence for targeting and destruction of the substrate by the 26S proteasome.