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商品編號(hào)


AG-44B-0004-KI01



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Antibodies



Size

1 Set


商品信息


More Information



Product Details



Product Type

Set



Properties



Application Set

Flow cytometry



Crossreactivity

Human



Kit Contains

100μg each of:
anti-TRAIL-R1 (clone HS101, Prod. No. AG-20B-0022);
anti-TRAIL-R2 (clone HS201, Prod. No. AG-20B-0023);
anti-TRAIL-R3 (clone HS301, Prod. No. AG-20B-0024);
anti-TRAIL-R4 (clone HS402, Prod. No. AG-20B-0025).



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



Manual

No



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





TRAIL-R1, -R2, -R3 and -R4 are receptors for the cytotoxic ligand TRAIL. When signaling through TRAIL-R1 and -R2, the adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. They promote the activation of NF-κB. TRAIL-R3 lacks a cytoplasmic death domain, and TRAIL-R4 contains a truncated death domain, and hence are not capable of inducing apoptosis. They protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.